The presenter will address our challenges in achieving health and delivering safe, effective, high-value healthcare. The session will examine changing incentives and the new business case for safety and quality. Approaches to organizational transformation, health technologies, and changing clinician behaviors in the era of zero tolerance for healthcare-associated infections will be discussed.;Objectives: Objectives: • Describe how resolving breeches of safety and improving quality (including underuse and overuse of health services) are critical business strategies for successful healthcare providers in the coming decade • Quantify the escalation of healthcare costs in the public and private sector • Employ evidence-based techniques to transform organizational and clinician behavior