Student-focused differentiation is the basis of one online staff development module associated with a Javits-funded study of cluster grouping. This module details and provides examples of 25 strategies that teachers can use to differentiate curriculum and instruction. The presenter reviews the instructional design process from start to finish and the resulting implications that apply to creating effective and engaging online learning modules for professional development. Responses from teachers across the country to the instructional technologies used in this module as well as how they implemented the content within their classrooms are provided.