Granulocyte Biology: Clinical Consequences of Gene Polymorphisms and Mutations
Program Code: 205-S
Sunday, October 24, 2004
8:30 AM to 10:00 AM (ET)

SPEAKERS
David Stroncek, MD, Department of Transfusion Medicine, CC
Harry Malech, MD, National Institues of Health
James A. Taylor, Ph. D, National Heart Lung, and Blood Institute

DESCRIPTION
Granulocytes are critical for host defense against bacteria and fungi. Recent advances in molecular biology have lead to the characterization of most genes expressed by granulocytes. Many of these genes have clinically important polymorphisms. This session will provide current information about important polymorphisms and mutations in granulocyte genes. The effects on host immune response of polymorphisms in granulocyte genes alone and in combination with other polymorphisms will be discussed. In addition, the role of mutations in neutrophil elastase on myelopoiesis will be reviewed. Clinical strategies that are being used to treat patients with congenital mutations effecting granulocyte function will be presented at the conclusion of the session.

OBJECTIVES

• Identify important polymorphisms and mutations in genes expressed by granulocytes
• Explain the clinical consequences of important granulocyte gene polymorphisms
• Describe strategies used to treat diseases that are due to mutations in genes expressed by granulocytes

AUDIENCE
Physicians, Scientists, Technologists

PROGRAM LEVEL
Advanced