Intravenous immunoglobulin (IVIG) is used to treat both primary and secondary immune deficiencies along with a variety of autoimmune and inflammatory disorders. IVIG products are safe and effective for their labeled use. IVIG contains IgG against blood group A and B antigens, and adverse transfusion reactions have been reported. In addition, IVIG therapy can result in false positive tests for infectious markers, which can complicate patient testing. This audioconference will review the use of IVIG in the management of immune disorders, the adverse immune reactions and its effect on patient testing.