The process of hematopoietic stem cell donation begins with the assessment of donor eligibility and suitability, proceeds through the safe and efficient collection of the cells and ends with the proper labeling, handling and distribution of the final product. These steps are required to ensure the well being of the donor, recipient and healthcare professionals who handle the hematopoietic progenitor cells collected by apheresis (HPC-A) or marrow harvest (HPC-M). In this audioconference, case studies and hypothetical situations will be utilized to highlight and discuss the medical challenges, regulatory implications and management strategies of HPC-A and HPC-M donors with transmissible communicable disease risk factors and/or medical comorbidities. The requirements for documentation and justification of donors with potential disqualifying clinical or laboratory features will be reviewed as well as the proper steps for documentation, labeling and, when necessary, investigation of products that deviate from accepted standards.