Human tissues in transplantation and reconstruction have been used by surgeons for several decades. Yet in many aspects quality systems in Good Tissue Practices (GTP) have not been fully embraced. Federal regulations are specific for the manufacturer or the tissue processor but such regulations do not reach into the clinical setting. Consequently, medical oversight and compliance to voluntary standards are needed to enhance and continue the quality elements of GTP. This audioconference will pose tissue related questions and challenges faced by the tissue processor, tissue bank, the medical director, and tissue coordinator in embracing Regulations and GTP.