Session Information
14th Annual Green Chemistry and Engineering Conference
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Alkali base-promoted C-C bond coupling of secondary alcohols with primary alcohols
Track : June 21, 2010
Program Code: 048
Date: Monday, June 21, 2010
Time: 3:30 PM to 3:50 PM  EST
Location: Capital Hilton - South American AB
CONTRIBUTOR :
Robert H. Crabtree
SPEAKER :
Laura J. Allen, Department of Chemistry, Yale University, New Haven, CT, United States
Description
Avoiding precious metals is a green strategy in catalysis. We now show how simple alkali bases promote the reaction of secondary alcohols with primary alcohols to give the -alkylated product in high conversions and yields. Transition metals, and even precious metals, were needed as catalysts in all previous work on this reaction. This system minimizes the formation of waste, avoids the use of protecting groups, such as silyl ethers, and maximizes atom economy, leaving only water as a by-product.


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