This course will present a series of difficult cases in evolving multidisciplinary management of breast cancer commonly seen in clinical practice. The audience will interact by first indicating their choice of management and national experts will discuss their preferred choice of management. At the conclusion of this activity, the learner will be able to do the following: 1. Identify clinical settings where RT (and best technique) is or isn't indicated when dealing with difficult and evolving areas in breast cancer. 2. Recognize clinical settings where systemic therapy (and best regimen) is indicated. 3. Recognize clinical settings where surgery (and best technique) is indicated.