In the conformal radiation therapy era (3D-CRT, IMRT, SBRT), the need for optimal imaging strategies is paramount for diagnosis and tumor delineation. The session will provide updates on the staging and treatment of GI tract neoplasms, specifically hepatocellular (HCC), pancreas and anorectal cancers. The current role for CT and MR imaging for staging and radiation target delineation for HCC, pancreas and rectal cancers will be reviewed. There will be a focus on differentiating HCC from benign perfusion abnormalities and diagnosing tumor thrombosis in the portal or hepatic veins. The evolving role of MRI in the staging of rectal cancers will be discussed as well as contouring of targets for patients treated with IMRT for anal and rectal cancer. Optimized imaging, whether by CT or MRI, is necessary to properly identify those patients with pancreatic adenocarcinoma who will benefit from immediate surgery (resectable), possible neo-adjuvant therapy (borderline resectable) or non-surgical therapy (unresectable). This session will discuss optimal imaging for pancreatic adenocarcinoma.