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Session Information

ENDO 09 Annual Meeting

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CLINICAL - Lessons Learned: From Genetic Causes of Hypopituitarism

Track : CLINICAL

Program Code: S23-2

Date: Thursday, June 11, 2009

Time: 10:00 AM to 10:30 AM EST

SPEAKER (S):

WF Crowley, MD, Massachusetts Gen Hosp.
Disclosure: Nothing to disclose

William F. Crowley Jr., M.D., is a Professor of Medicine at Harvard Medical School and the Director of Harvard Medical School�s Center of Excellence in Reproductive Endocrinology, one of 13 competitive NICHD funded Centers. A graduate in the Honors Curriculum of Holy Cross College who received his M.D. from Tufts University School of Medicine, Dr. Crowley trained in Internal Medicine and Endocrinology at the Massachusetts General Hospital (MGH) from 1969 and has remained on the Harvard Medical School faculty ever since. There he has established a broad-based translational research program in the Reproductive Endocrine Unit which was established as an independent Unit in the Department of Medicine around his research program in 1984. During his 39-year tenure at the MGH, Dr. Crowley and his colleagues pioneered the use of GnRH analogue treatment for children with precocious puberty, establishing the principle of GnRH agonist-induced pituitary desensitization as a therapy that obtained FDA approval. This treatment is now used for prostate cancer, endometriosis, and uterine fibroids and represents a $2B annual pharmaceutical market. In addition, he went on to develop the use of pulsatile GnRH to induce ovulation in infertile women, puberty, and fertility in men with absent or delayed puberty. Most recently, he and his colleagues have established a robust investigative platform to identify several new genes that are responsible for human puberty using genetic and molecular approaches in the GnRH deficient human model. Dr. Crowley has served as the Director of Clinical Research at the MGH for the past 13 years. He is also the Founder and current President of the Clinical Research Forum, an association of 65 of the country�s leading academic medical centers and leading human disease foundations that collectively account for ~80% of all of NIH�s extramural research funding. The Forum focuses on improving the national infrastructure to attract the best and brightest physician scientists into human research and provide the milieu to nourish and retain them in clinical investigation in the US. He was a member of the Institute of Medicine�s Clinical Research Roundtable where he authored 2 important JAMA articles that defined the national scope of problems of clinical research and outlined some potential solutions. For these accomplishments, Dr. Crowley has received the NIH�s General Clinical Research Center National Award and the Endocrine Society Awards for Excellence in Clinical Research. He was named an Honorary Fellow in the Royal Society of Medicine (Ire) and was the first male to receive the Mentor of the Year Award from Women in Endocrinology. He served as President of the Endocrine Society from 2001-02 and in 2005, he received the Fred Conrad Koch Award, the Endocrine Society�s highest scientific award. In 2007, he was awarded the IPSEN Fondation Award for Endocrine Research an international juried prize in endocrinology whose previous awardees include Pierre Chambon, Robert Lefkowitz, and Wylie Vale.

S Vallette, MD, PhD, Ctr Hosp Univ de Montr[eacute]al
Disclosure: Nothing to disclose

Audio Synchronized to PowerPoint

(Code: S23-2)

This session is a part of:

Complete Clinical and Translational Meeting Compilation (Online Access + DVD-ROM)