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Session Information

ENDO 2011 Annual Meeting

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Mitochondrial Dysfunction in Obesity & Diabetes: Chicken or Egg?

Track : TRANSLATIONAL

Program Code: S44-3

Date: Monday, June 6, 2011

Time: 10:30 AM to 11:00 AM EST

Location: 153ABC

SPEAKER :

Mary Elizabeth Patti, MD, Joslin Diab Ctr/Harvard Med
Disclosure: Nothing to Disclose

The laboratory of Mary-Elizabeth Patti, MD focuses on mechanisms by which environmental or nutritional risk factors (e.g. obesity, prenatal and early postnatal nutrition) influence gene expression and metabolic function in tissues critical for insulin sensitivity and glucose tolerance. Her laboratory has demonstrated that a consistent pattern associated with type 2 diabetes is impaired expression of nuclear-encoded genes controlling enzymes critical for mitochondrial oxidative metabolism. In turn, this pattern is linked to intracellular accumulation of potentially pathogenic lipid species. Current studies are focused on analyzing patterns of gene expression and cellular metabolites in muscle, adipose, and liver of normoglycemic individuals with �prediabetes,� or diabetes risk, in order to identify early mechanistic changes which may be targets for prevention and therapy. To better understand the relationship between early life nutritional exposures, epigenetic changes, and diabetes risk, Dr. Patti has developed mouse models of developmental risk for diabetes and obesity, mediated by an adverse nutritional environment during prenatal and early postnatal life. Dr. Patti received her undergraduate and medical degrees through an accelerated medical school program at Jefferson Medical College, followed by internal medicine residency at the University of Pittsburgh, and training in the joint Harvard Medical School endocrinology fellowship program. She is currently Investigator, Director of the Joslin Genomics Core, and Director of the Hypoglycemia and Severe Insulin Resistance Clinic (all at Joslin Diabetes Center), and Assistant Professor of Medicine, Harvard Medical School. She was elected to the American Society of Clinical Investigation in 2009.

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(Code: S44-3)

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ENDO 2011 Annual Meeting Full Conference Online Access