With a non-labor expense spend of nearly $500 million, SFFHS launched a system-wide Non-Labor Cost Reduction effort which focused on all categories of supplies, purchased services, and non-salary human resource expenses. As a multi-regional health system spread across northwest Indiana and south suburban Chicago, SSFHS commissioned teams at the corporate level, system level shared services, and at the regional/local hospital level to tackle the initiative. Participants will learn how SSFHS launched a comprehensive organizational effort which included active participants of several dozen teams of administrators, physicians, pharmacists, clinicians, ancillary professionals, support service staff, financial staff, and information technology team members. Seeking to incorporate efficiency improvements into ongoing operational protocols, the session participants will learn how SSFHS implemented sustainability measures in over 500 unique opportunities to insure the continuation cost reduction processes, accountability, and reporting. The presenters will share their approaches to change management, benefit measurement, and the use of six sigma methods employed to insure the continued effectiveness and long-term cultural adoption of non-labor cost reduction.