This didactic session will review skeletal changes over the lifespan. A session on childhood and adolescence will cover skeletal growth, the impact of nutrition, activity and other contributors to bone accrual. Changes in skeletal status after peak bone mass attainment will be discussed to include sex hormone depletion, the impact of chronic diseases, lifestyle and efforts to maintain bone density or prevent loss. Issues of skeletal health in the elderly will include frailty, falls, fracture, polypharmacy, quality of life and interventions to improve skeletal status. The session will conclude with an interactive panel discussion.