ASTRO Virtual Meeting Center

radiation oncologist specializing in head and neck cancer

Dr. Carol A. Hahn's clinical interest include breast cancer, neuropsychologic effects of cancer therapy, and depression and anxiety in cancer patients. While her research interests include development of evidence based clinical practice guidelines for radiation oncology, assessment of patient anxiety and depression in oncology, clinical trials examining patient education methods as well as therapeutic interventions to decrease anxiety and depression levels in oncology patients and improve quality of life, analysis of patterns of utilization of therapeutic modalities for breast and prostate cancer, disparities in care for oncology patients between tertiary care and community hospitals, assessment of neuropsychologic function in brain tumor patients and the metabolic and functional changes induced by radiation therapy,and normal tissue toxicities related to Radiotherapy and use of functional imaging tools to predict outcomes of clinical significance.

I have conducted extensive research related to radiation-induced normal tissue injury. I have received grants and have written many papers on this topic. I have conducted research and development in the area of quality assurance and education.

Dr. Michalski is the Vice Chair of the RTOG and a recognized expert in prostate cancer and clnical trials utilizing advanced technology. He has published numerous articles on prostate cancer, 3D conformal radiation therapy, IMRT and SBRT.

Research interest: Molecular and functional immunofluorescent imaging of the tumor microenvironment, with emphasis on hypoxia and related signaling pathways. Recent publication: 215 Bussink J, van der Kogel AJ, Kaanders JHAM. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 9: 288-296 (2008). 195 Van Laarhoven H, Kaanders J, Lok J, Peeters W, Rijken P, Wiering B, Ruers T, Punt C, Heerschap A, van der Kogel AJ. Hypoxia in relation to vasculature and proliferation in liver metastases of patients with colorectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 64:473-482, 2006 193 Hoogsteen IJ, Pop LAM, Marres HAM, Merkx MAW, van den Hoogen FJA, van der Kogel AJ, Kaanders JHAM. Oxygen�modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck. Int J Rad Oncol Biol Phys 64: 83-89, 2006 Keynote and invited lectures: Singapore, 15-17 Nov 2006 Royal Australian & New Zealand College of Radiology. Invited keynote speaker. Lectures: 1) Radiobiology of the central nervous system. 2) Immunohistochemical studies of the effects of EGFR blockers and irradiation on tumor hypoxia, proliferation and associated signalling pathways Paris (France) 26-29 June 2007. Eurocancer Congress. Invited keynote lecture: Imaging, hypoxia dynamics and tumor microenvironment San Francisco (California) 8-12 July 2007. 13th International Congress of Radiation Research. Invited symposium presentation: "Tumor imaging with immunohistochemistry" Philadelphia (PA) Nov 2006. ASTRO � invited presentation Presidential Symposium �Biomarkers in head/neck cancer�