This session will review current and epidemiological changes in esophageal and gastric cancer as well as discuss current and future multimodality treatment strategies. At the conclusion of this activity, the learner will be able to do the following: 1. Define current epidemiological changes in esophageal and gastric cancers. 2. Discuss current treatment strategies of esophageal cancer: adjuvant and neoadjuvant treatment and surgery, definitive chemoradiation. 3. Summarize the future of treatment: newer randomized trials, alternative treatment strategies and integration of novel agents with radiation therapy. 4. Summarize case discussion.