Developing techniques to better understand the adsorption, distribution, metabolism and excretion (ADME) of novel investigational compounds presents unique challenges for the clinical research facility, academic or nonacademic, as well as the pharmaceutical industry. In this symposium, three differing approaches to examining the use of radio-labeled compounds will be explored. These different aspects of imaging technology are highly desirable tools in understanding drug mechanisms of action and deposition within either tumor spaces or other sites of action.

Learning Objectives:
Explain three benefits of using quantitative PET for measuring glucose utilization, metabolism and cell proliferation in clinical trials
Describe the 14-C IV dose compounding requirements in performing microtracer absolute bioavailability study using AMS
Describe the potential benefits of fluorescence correlation spectroscopy (FCS) as an alternative biomarker detection technique.