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Session Information

2008 Annual Meeting

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Joint ASTRO/RRS Tumor Regrowth Delay and Tumor Cure Assays: Design, Interpretation, and Relevance for Assessment of Radiocurability and its Modification

Track : PAN

Program Code: PAN05

Date: Monday, September 22, 2008

Time: 3:45 PM to 5:15 PM EST

Duration: 3320 Minutes

Location: 252

SPEAKER(S):

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Soren Bentzen, Ph.D., D.Sc., Professor, University of Wisconsin Medical School

Leo Gerweck, Massachusetts General Hospital

Howard Thames, M.D. Anderson Cancer Center

Albert van der Kogel, Professor, Radboud University Nijmegen Medical Center

Research interest: Molecular and functional immunofluorescent imaging of the tumor microenvironment, with emphasis on hypoxia and related signaling pathways. Recent publication: 215 Bussink J, van der Kogel AJ, Kaanders JHAM. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 9: 288-296 (2008). 195 Van Laarhoven H, Kaanders J, Lok J, Peeters W, Rijken P, Wiering B, Ruers T, Punt C, Heerschap A, van der Kogel AJ. Hypoxia in relation to vasculature and proliferation in liver metastases of patients with colorectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 64:473-482, 2006 193 Hoogsteen IJ, Pop LAM, Marres HAM, Merkx MAW, van den Hoogen FJA, van der Kogel AJ, Kaanders JHAM. Oxygen�modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck. Int J Rad Oncol Biol Phys 64: 83-89, 2006 Keynote and invited lectures: Singapore, 15-17 Nov 2006 Royal Australian & New Zealand College of Radiology. Invited keynote speaker. Lectures: 1) Radiobiology of the central nervous system. 2) Immunohistochemical studies of the effects of EGFR blockers and irradiation on tumor hypoxia, proliferation and associated signalling pathways Paris (France) 26-29 June 2007. Eurocancer Congress. Invited keynote lecture: Imaging, hypoxia dynamics and tumor microenvironment San Francisco (California) 8-12 July 2007. 13th International Congress of Radiation Research. Invited symposium presentation: "Tumor imaging with immunohistochemistry" Philadelphia (PA) Nov 2006. ASTRO � invited presentation Presidential Symposium �Biomarkers in head/neck cancer�

LEARNER OUTCOMES:

Assess the clinical significance of tumor response assays.
Critically assess the validity of tumor response assays.
Improve the design of tumor response assays.

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(Code: PAN05)

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