This session will focus on current methods for delineating tumor and organ contours from anatomic and molecular imaging data, including both current clinical standard techniques and emerging strategies such as automated image analysis, atlas-based approaches, implementation of 4DCT and motion management in modern radiation oncology practice. The use of minimally-invasive image-guided therapies for cancer will be covered; techniques described will include intra-arterial chemoembolization and radioembolization as well as tumor ablation with radiofrequency and microwave energy, cryoablation and irreversible electroporation.