The presenter will address the incidence/prevalence of C. difficile infection in U.S. hospitals as reported in the published literature. An overview of the design, methods, and results of the APIC C. difficile U.S. Prevalence Survey will be discussed. Prevention measures will be highlighted.;Objectives: *Describe estimates of the incidence of C. difficile infection in U.S. hospitals *Describe the design and results of the APIC C. difficile U.S. prevalence study *Explain C. difficile prevention measures