As a result of significant legislative efforts within the United States and European Union, pharmaceutical companies must address the pediatric population during the drug development process, and, when applicable, design and conduct pediatric trials in the appropriate pediatric age groups. Given the involvement of pediatric patients and their parents/guardians in the research study process, the special needs and considerations of the vulnerable patient population, and the crucial focus on ensuring safety and well-being of the pediatric study participants, conducting a pediatric research study most certainly involves unique challenges. This symposium will explore unique challenges, present insights, and offer best practices associated with pediatric trial recruitment, retention and blood sample collection.