This symposium will address a number of current clinical supplies topics, including managing the ever-growing costly needs of large-scale investigator-initiated studies (IIS)/investigator-initiated trials (IIT)/investigator-sponsored trials (IST) program management, mitigating risk in your interactive response technology (IRT) system's automated supply chain configuration, and an update on methods for maintaining regulatory compliance with continuously evolving import/export processes. Through a combination of instruction and case studies, our panel will surface recent developments in these areas that impact a broad spectrum of clinical operations stakeholders.