There are several barriers to developing and disseminating technology, including small scale of producer, lack of complete patient population data, and unfavorable economics/governance. Nonprofit-industry partnerships can help overcome these barriers. This session will present three examples highlighting unique aspects of the collaborations: A foundation's $16 million funding effort to disseminate technology for simulating virtual patient populations, the Merck- Regenstrief Institute partnership and the co-development and dissemination of technology to support real-world evidence-based research and health care innovation, and a university's direct investment in creating its own startups.