This symposium will provide multiple perspectives on selecting, implementing, and getting the most out of an EDC system. Insight will be provided on the factors to consider and the critical questions to ask in order to choose the best EDC platform for an organization or clinical study. Attendees will also learn to determine which EDC-related challenges can be fixed through process re-engineering and change management, which issues truly necessitate switching to a new system, and the challenges and costs associated with moving to a new system. Finally, attendees will hear about current trends for using alternative EDC solutions in postmarketing studies.