Currently three documents serve to communicate patient product information, the Patient Package Insert (PPI), Medication Guide, and Consumer Medication Information (CMI). None are deemed optimal as a 'One Document Solution'. Over the past 20 years FDA has collaborated with multiple healthcare stakeholders to explore how to effectively communicate the most useful prescription medication information to patients. This session will discuss two pilot projects that were conducted with one-page Patient Medical Information (PMI) samples to determine, amongst other objectives, patient comprehension and patient preferences for format, content and method of receipt.