Clinical trials are considered the gold standard for determining the efficacy of a therapeutic but operate in an idealized patient setting, only measuring efficacy in restrictive populations. As such, they may not provide a true indication of effectiveness within a diversified target population. Data retrieved from electronic medical records (EMRs) allow for the examination of health care utilization patterns and associated outcomes in a real-world setting. This unique data collection approach will provide new insights on therapeutic treatment options used in practice for minimal cost, time and effort. This session will present real-world examples in solid organ transplantation to illustrate the challenges in utilizing site EMR systems.