Safety-related warnings and market withdrawals of prominent drugs in recent years have fueled efforts to explore other data sources and develop new methodologies in order to offset the limitations of existing safety signal detection systems. One of the important resources proposed as having enormous potential for proactive surveillance are electronic health records (EHRs). There are various initiatives that have been launched worldwide to investigate the secondary use of EHRs for this purpose. In this session, we will give an update on these ongoing initiatives.