This symposium will discuss the advantages and disadvantages of a few methodologies that are directly related to implementation of adaptive designed trials. A weighted average approach on the type I error and type II error will be introduced and will be compared with the standard approach where type I error is fixed and type II error is to be minimized. As for randomization, a hybrid randomization algorithm will be presented, which will be contrasted with conventional randomization to illustrate the pros and cons among the algorithms. Finally, adaptive dose finding designs including penalized D-optimal design, CRM design and Bayesian adaptive designs will be compared. In addition, the tradeoff between the desire to maximize information and various constraints will be discussed while gaining information under ethical/cost constraints in adaptive dose finding studies.